SPM Active® renews the body’s natural capacity to soothe tissues and maintain a healthy inflammatory balance. These Specialized Pro-Resolving Mediators (SPMs) — 18-HEPE, 17-HDHA, and 14-HDHA — are next-generation lipid mediators derived from omega-3 fatty acids that play a key role in restoring homeostasis after physical stress or discomfort.*
Formulated with a proprietary Active Fractionated Marine Lipid Concentrate, SPM Active® helps:
Reduce joint and muscle soreness after physical exertion††
Promote healthy inflammation resolution rather than simple suppression*
Support mobility, flexibility, and recovery for active lifestyles*
Clinical research published in the Journal of Translational Medicine demonstrated that 36% of participants reported decreased soreness and discomfort after two weeks of SPM Active® supplementation (1.5 g daily).††
Each serving provides 1 gram of active fractionated marine lipids standardized to naturally occurring SPM molecules. Free of gluten and non-GMO, this formula is ideal for those seeking targeted, evidence-based support for musculoskeletal comfort and recovery.*
Suggested Use
Take two softgels once daily or as directed by your healthcare practitioner.
Supplement Facts
| Serving Size | 2 Softgels |
|---|---|
| Calories | 10 |
| Total Fat | 1 g |
| Cholesterol | <5 mg |
| Active Fractionated Marine Lipid Concentrate† | 1 g |
| SPM content standardized to: | 18-hydroxy-eicosapentaenoic acid (18-HEPE), 17-hydroxy-docosahexaenoic acid (17-HDHA), 14-hydroxy-docosahexaenoic acid (14-HDHA) |
Other Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, and mackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin, and water), and silica.
Contains: Fish (anchovy, sardine, and mackerel).
Non-GMO. Gluten-Free.
†Lipinova® is a registered trademark of Solutex.
††Callan N, et al. J Transl Med. 2020;18(1):401.
†US Patents 11,077,083 and 11,077,084.
Caution:
If pregnant, nursing, or taking medications, consult your healthcare practitioner before use. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Tamper Evident: Do not use if safety seal is missing or broken.
Frequently Asked Questions
What is SPM Active® used for?
SPM Active® supports the body’s natural ability to resolve joint and muscle discomfort by promoting healthy inflammatory balance and recovery after physical activity. It provides specialized pro-resolving mediators (SPMs) derived from marine lipids to assist in tissue restoration and comfort.*
How does SPM Active® work?
SPM Active® contains three key Specialized Pro-Resolving Mediators—18-HEPE, 17-HDHA, and 14-HDHA—that help the body transition from the inflammatory phase to the resolution phase. Rather than blocking inflammation, these SPMs support the body’s natural recovery and healing responses.*
Is SPM Active® safe to take long-term?
Yes. Clinical research supports the safety and efficacy of daily SPM supplementation for maintaining healthy inflammatory function and musculoskeletal comfort. Always consult your healthcare practitioner before beginning any new supplement regimen.*
Does SPM Active® contain fish or allergens?
Yes. SPM Active® contains fractionated marine lipid concentrate derived from anchovy, sardine, and mackerel. It is non-GMO, gluten-free, and purified through a patented process to ensure high-quality, sustainable sourcing.*
Who manufactures SPM Active®?
SPM Active® is manufactured by Metagenics®, a leading nutraceutical company specializing in science-based clinical formulas. The marine lipid concentrate used in this product is developed using Lipinova® technology from Solutex and protected by U.S. Patents 11,077,083 and 11,077,084.*
‡This content is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.