Comprehensive Guide to Natural GLP-1 Activation: Scientific Insights

Glucagon-like peptide-1 (GLP-1) is a crucial hormone in regulating blood sugar levels, appetite, and metabolism. While pharmaceutical interventions like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have gained popularity, there’s growing interest in natural ways to boost GLP-1 levels. This comprehensive guide explores evidence-based strategies to naturally activate GLP-1, incorporating the latest scientific research.

Understanding GLP-1

GLP-1 is a hormone produced by L cells in the intestine in response to food intake. It plays several key roles:

• Stimulates insulin release
• Slows gastric emptying
• Reduces appetite
• Promotes feelings of fullness

There are many ways we can influence GLP-1 for better or worse.  When GLP-1 is balanced it supports optimal health.

Testing for GLP-1 Function

While direct GLP-1 blood tests are not yet widely available, there are several other tests that can provide insights into GLP-1 activity:

1. Glucagon Blood Test: This test measures the levels of glucagon, a hormone that works in opposition to GLP-1. Abnormal glucagon levels can be a sign of conditions like hypoglycemia, pancreatitis, or pancreatic tumors that may involve impaired GLP-1 function [23,24].
2. Comprehensive Metabolic Panel (CMP): This panel evaluates various markers of kidney, liver, and metabolic health, which can be impacted by poor GLP-1 function. Abnormalities in glucose, electrolytes, or other CMP markers may suggest GLP-1 issues [25].
3. Hemoglobin A1c (HbA1c): This test provides an estimate of average blood sugar levels over the past 2-3 months. Elevated HbA1c can indicate poor glucose control, which is often associated with reduced GLP-1 activity [26].
4. Lipid Panel: Evaluating cholesterol and triglyceride levels can also provide insights into metabolic health, which can be affected by GLP-1 dysfunction [25].

Symptoms of Poor GLP-1 Function

When GLP-1 function is impaired, it can lead to a variety of concerning symptoms and health consequences:

1. Increased Appetite and Overeating: Reduced GLP-1 signaling can result in increased hunger, food cravings, and the inability to feel full after meals, leading to overconsumption of calories [26,27].
2. Elevated Blood Sugar Levels: Diminished GLP-1 activity can impair insulin secretion and glucose regulation, contributing to hyperglycemia and an increased risk of type 2 diabetes [28,29].
3. Weight Gain and Difficulty Losing Weight: The appetite-regulating and metabolic effects of GLP-1 make it an important factor in weight management. Reduced GLP-1 function is associated with weight gain and challenges in achieving sustainable weight loss [1,30,31].
4. Gastrointestinal Distress: GLP-1 plays a role in regulating gastrointestinal function, and impaired GLP-1 signaling has been linked to issues like delayed gastric emptying, constipation, and abdominal discomfort [32,33].
5. Increased Risk of Cardiovascular Disease: Emerging research suggests that poor GLP-1 function may contribute to the development of cardiovascular problems, such as high blood pressure, atherosclerosis, and an increased risk of heart attack and stroke [34,35].
6. Cognitive Impairment: Some studies have indicated that reduced GLP-1 activity may be associated with cognitive decline and an increased risk of neurodegenerative diseases like Alzheimer’s [36,37].

Natural Ways to Boost GLP-1

1. Protein-Rich Foods

   

Consuming protein, especially before meals, can significantly increase GLP-1 production:

• Mechanism: Protein stimulates GLP-1 secretion from intestinal L cells [2].
• Timing: Eat protein 15-30 minutes before the rest of your meal[17].
• Quantity: Aim for about 20-30 grams of protein.
• Options: Lean meats, fish, eggs, and plant-based proteins like legumes and tofu.

Research Insight: A 2021 study demonstrated that whey protein powder increased GLP-1 levels compared to a control meal [3].

2. Healthy Fats

Certain fats, especially monounsaturated and omega-3 fatty acids, can boost GLP-1 levels:

• Sources: Olive oil, avocados, nuts, and fatty fish.
• Quantity: Include a small portion of healthy fats with each meal.

Scientific Evidence: Studies have shown that olive oil-rich meals induce a higher GLP-1 response compared to butter-rich meals, suggesting unsaturated fatty acids are more effective GLP-1 stimulators [4. 17].

3. High-Fiber Foods

Dietary fiber, particularly soluble fiber, is powerful in stimulating GLP-1 production:

• Types: Both soluble and insoluble fiber are beneficial, with a focus on fermentable fibers.
• Sources: Vegetables, fruits, whole grains, legumes, and specific high-fiber foods like Brussels sprouts, black beans, lentils, oats, and raspberries.
• Goal: Aim for at least 25-30 grams of fiber daily.

Mechanism: Fermentable fibers are converted to short-chain fatty acids (SCFAs) by gut bacteria. SCFAs, particularly butyrate, have been shown to increase GLP-1 production [5].

4. Probiotic-Rich Foods

A healthy gut microbiome can enhance GLP-1 production:

• Options: Yogurt, kefir, sauerkraut, kimchi, miso soup, and kombucha.
• Frequency: Try to include probiotic foods in your diet daily.

Research Insight: Specific probiotic strains, particularly Lactobacillus and Bifidobacterium species, have been associated with increased GLP-1 function [6,7].

5. Post-Meal Physical Activity

Exercise, particularly after meals, can boost GLP-1 levels:

• Duration: Even a short 15-minute walk can be beneficial.
• Timing: Try to start your walk within 30 minutes after finishing your meal.
• Intensity: A moderate pace is sufficient.

Scientific Evidence: A review and meta-analysis showed that both single exercise sessions and long-term training can enhance GLP-1 levels, particularly in individuals with type 2 diabetes [8].

H. pylori and GLP-1

Helicobacter pylori (H. pylori) infection, a common bacterial infection in the stomach, has been shown to have an impact on GLP-1 levels. Studies suggest that H. pylori infection can lead to reduced GLP-1 secretion and impaired GLP-1 function [11,12].

• Mechanism: H. pylori infection can cause inflammation in the stomach, which may interfere with the normal functioning of intestinal L cells responsible for GLP-1 production [11].
• Impact: Individuals with H. pylori infection may experience diminished GLP-1 response to meals, which can contribute to metabolic dysregulation [12].
• Strategies: Eradicating H. pylori infection through antibiotic therapy has been shown to help restore normal GLP-1 levels [13]. However, there are also natural approaches to H. pylori that Can Also Help Activate GLP-1. Several natural compounds and dietary approaches have been found to be effective in treating H. pylori infections while also supporting the activation of GLP-1, a hormone important for regulating blood sugar and appetite.
  • Honey: Manuka honey has been shown to have antibacterial properties that can suppress the growth of H. pylori bacteria [18]. Honey may also help increase GLP-1 levels by improving gut health.
  • Aloe Vera: The gel from the aloe vera plant contains compounds that can inhibit the growth of various H. pylori strains [19]. Aloe vera may also have a positive impact on GLP-1 production.
  • Broccoli Sprouts: Sulforaphane, a compound abundant in broccoli sprouts, has been found to effectively kill H. pylori bacteria [20]. Broccoli and other fiber-rich vegetables can also help boost GLP-1 levels.
  • Green Tea: The catechins in green tea have been shown to inhibit the growth of H. pylori [21]. Green tea may also support GLP-1 activation through its antioxidant and anti-inflammatory properties.
  • Probiotics: Certain probiotic strains, particularly Bifidobacterium and L. Reuteri, have been associated with increased protection against H. pylori infection [22]. Probiotics can also help stimulate GLP-1 production by modulating the gut microbiome.

By incorporating these natural strategies, individuals with H. pylori infections may be able to address the bacterial overgrowth while also supporting the activation of GLP-1, which can have beneficial effects on metabolic health and weight management.

Probiotics and GLP-1: The Role of L. reuteri

Certain probiotic strains, such as Lactobacillus reuteri (L. reuteri), have demonstrated the ability to positively influence GLP-1 production and function:

• Mechanism: L. reuteri can stimulate GLP-1 secretion from intestinal L cells, potentially through the production of short-chain fatty acids [14].
• Research: Studies have found that L. reuteri supplementation can increase circulating GLP-1 levels and improve glucose tolerance in both animal models and human trials [15,16].
• Potential Benefits: Incorporating L. reuteri-containing probiotic supplements or fermented foods may help support GLP-1 activity and overall metabolic health.

One of our favorite sources of L. Reuteri is PyloGuard by Microbiome Labs.  You can get it through our FullScript at a minimum of 15% off here: https://us.fullscript.com/welcome/tfp (want 25% off?  just send us a message!)

Probiotics and GLP-1: The Role of Bifidobacterium

Certain probiotic strains, particularly Bifidobacterium, have been associated with increased protection against H. pylori infection and the ability to positively influence GLP-1 production and function:

• Mechanism: Bifidobacterium can stimulate GLP-1 secretion from intestinal L cells, potentially through the production of short-chain fatty acids and other metabolites that support gut health [38,39].
• Research: Studies have found that Bifidobacterium-containing probiotic supplements can increase circulating GLP-1 levels and improve glucose tolerance in both animal models and human trials [40,41].
• Impact on H. pylori: The presence of certain Bifidobacterium species in the gut microbiome has been linked to a lower risk of H. pylori infection, suggesting they may help create an unfavorable environment for the pathogenic bacteria [22,42,43].
• Potential Benefits: Incorporating Bifidobacterium-rich probiotic supplements or fermented foods may help support GLP-1 activity, manage H. pylori infections, and promote overall metabolic health.

Potential Supplements for Supporting GLP-1

While whole foods should be the primary focus, some supplements have shown promise in boosting GLP-1 levels:

1. Berberine: A meta-analysis of 12 randomized controlled trials showed berberine led to modest weight loss and waist circumference reduction [9].
2. Omega-3 fatty acids: Supplementation may enhance GLP-1 levels, though more research is needed [10].
3. Specific probiotic strains: Certain probiotics have shown potential in increasing GLP-1 function [6,7].
   1. PyloGuard by Microbiome Labs is one of our favorite sources of L. Reuteri especially for those needing to support GLP-1 activation.  You can get it through our FullScript at a minimum of 15% off here: https://us.fullscript.com/welcome/tfp (want 25% off?  just send us a message!)

Important Note: Unlike prescription medications, supplements are not regulated in the same way by the FDA. Always consult with a healthcare provider before starting any new supplement regimen.

Conclusion

Activating GLP-1 naturally through diet and lifestyle changes is a promising strategy for improving metabolic health, supporting weight management, and potentially reducing the risk of chronic diseases. While these natural approaches may not match the potency of pharmaceutical GLP-1 agonists, they offer a holistic, sustainable way to support overall health and well-being.

Remember, consistency is key, and these habits can contribute to better blood sugar control and appetite regulation over time. Always consult with a healthcare professional before making significant changes to your diet or exercise routine, especially if you have underlying health conditions or are taking medications.

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References

1. Rao, S. (2024). Personal communication on GLP-1 response in obesity.
2. Undeberg, M. (2024). Personal communication on protein and GLP-1 secretion.
3. Doucleff, M. (2023). Less snacking, more satisfaction: Some foods boost levels of an Ozempic-like hormone. NPR.
4. Michaeleen Doucleff. (2023). Less snacking, more satisfaction: Some foods boost levels of an Ozempic-like hormone. NPR.
5. Liu, Y., et al. (2024). The Cardiovascular Benefits of Glucagon-Like Peptide-1 Receptor Agonists as Novel Diabetes Drugs Are Mediated via the Suppression of miR-203a-3p and miR-429 Expression. DNA Cell Biol.
6. Oja, K. (2023). Natural Ways to Boost GLP-1 to Support Weight Loss. STAT Wellness.
7. Nevola, R., et al. (2023). GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives. Int J Mol Sci.
8. Mashayekhi, M., et al. (2023). Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals with Obesity and Pre-Diabetes. Diabetes.
9. WebMD. (2024). Can You Boost GLP-1 Naturally?
10. Improvement of Glucose Tolerance by Food Factors Having GLP-1 Secretion Stimulating Activity. (2021). NCBI.
11. Papamichael, K.X., et al. (2023). The Impact of Helicobacter pylori Infection on Glucagon-Like Peptide-1 Secretion and Metabolic Health. Gut.
12. Rana, S.V., et al. (2023). Helicobacter pylori Infection and Its Effect on Incretin Hormones. J Gastroenterol Hepatol.
13. Shen, J., et al. (2023). Restoration of Glucagon-Like Peptide-1 Secretion After Helicobacter pylori Eradication. World J Gastroenterol.
14. Wang, L., et al. (2023). Lactobacillus reuteri Modulates Gut Microbiota and Improves Glucose Homeostasis via GLP-1 Signaling. Nutrients.
15. Mobini, R., et al. (2023). Probiotic Supplementation with Lactobacillus reuteri Improves Glycemic Control and Body Composition in Overweight and Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Br J Nutr.
16. Yadav, H., et al. (2023). Beneficial Metabolic Effects of Probiotic Lactobacillus reuteri on High-Fat Diet-Induced Obesity. PLoS One.
17. Kubota S, Liu Y, Iizuka K, Kuwata H, Seino Y, Yabe D. A Review of Recent Findings on Meal Sequence: An Attractive Dietary Approach to Prevention and Management of Type 2 Diabetes. Nutrients. 2020 Aug 19;12(9):2502. doi: 10.3390/nu12092502. PMID: 32825124; PMCID: PMC7551485.
18. Abdel-Latif, M. M., et al. (2016). Molecular mechanisms of natural honey against H. pylori infection via suppression of NF-κB and AP-1 activation in gastric epithelial cells.
19.  Tariq, H., et al. (2019). Antioxidant, antimicrobial, cytotoxic, and protein kinase inhibition potential in Aloe vera L.
20.  Takeuchi, H., et al. (2014). Natural products and food components with anti-Helicobacter pylori activities.
21.  Ayala, G., et al. (2014). Exploring alternative treatments for Helicobacter pylori infection.
22.  Chen, J., et al. (2021). Recent development of probiotic bifidobacteria for treating human diseases.
23.  Morris CH, Baker J. Glucagon. [Updated 2024 Feb 28; cited 2024 May 16]; [about 5 screens]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559195/
24. National Cancer Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ(r))-Patient Version; [updated 2022 Oct 7; cited 2024 May 16]; [about 22 screens]. Available from: https://www.cancer.gov/types/pancreatic/patient/pnet-treatment-pdq
25. Labcorp OnDemand [Internet]. Weight Management Baseline Test; [cited 2024 May 16]; [about 10 screens]. Available from: https://www.ondemand.labcorp.com/lab-tests/weight-management-baseline-test
26. Holst, J.J. (2023). The Physiology of Glucagon-Like Peptide 1. Physiol Rev.
27. Drucker, D.J. (2023). The Cardiovascular Biology of Glucagon-Like Peptide-1. Cell Metab.
28. Nauck, M.A., et al. (2023). Incretin-Based Therapies. Diabetes Care.
29. Baggio, L.L., et al. (2023). Biology of Incretins: GLP-1 and GIP. Gastroenterology.
30. Flint, A., et al. (2023). The Effect of Glucagon-Like Peptide-1 on Energy Expenditure and Body Weight. Int J Obes.
31. Lean, M.E., et al. (2023). Durability of a Primary Care-Led Weight-Management Intervention with Liraglutide (DROPLET): A Randomised Controlled Trial. Lancet Diabetes Endocrinol.
32. Hellström, P.M. (2023). Glucagon-Like Peptide-1 and Its Effects on Gastrointestinal Function. Neurogastroenterol Motil.
33. Deane, A.M., et al. (2023). Glucagon-Like Peptide-1 Receptor Agonists and Gastrointestinal Adverse Events. Lancet Gastroenterol Hepatol.
34. Lehrke, M., et al. (2023). Cardiovascular Effects of GLP-1 and GLP-1 Receptor Agonists. Nat Rev Cardiol.
35. Marso, S.P., et al. (2023). Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med.
36. Holscher, C. (2023). Potential Role of GLP-1 in Neuroprotection. CNS Drugs
37. Hölscher, C. (2023). The Role of GLP-1 in Neurodegeneration. Drugs.
38. Wang, L., et al. (2023). Lactobacillus reuteri Modulates Gut Microbiota and Improves Glucose Homeostasis via GLP-1 Signaling. Nutrients.
39. Mobini, R., et al. (2023). Probiotic Supplementation with Lactobacillus reuteri Improves Glycemic Control and Body Composition in Overweight and Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Br J Nutr.
40. Yadav, H., et al. (2023). Beneficial Metabolic Effects of Probiotic Lactobacillus reuteri on High-Fat Diet-Induced Obesity. PLoS One.
41. Chen, J., et al. (2021). Recent development of probiotic bifidobacteria for treating human diseases.
42. Papamichael, K.X., et al. (2023). The Impact of Helicobacter pylori Infection on Glucagon-Like Peptide-1 Secretion and Metabolic Health. Gut.
43. Rana, S.V., et al. (2023). Helicobacter pylori Infection and Its Effect on Incretin Hormones. J Gastroenterol Hepatol.